CTNPT 015: COMO cognition study with HIV+ patients

Study Approach

The researchers will use both standard neuropsychological testing and questionnaires, as well as a computerized battery for assessment of cognition. The questionnaires and standard neuropsychological tests will be administered in French or English depending on the participants first language. In order to make sure that there is no condition other than HIV itself that can explain the cognitive decline, the patients will first undergo a complete examination by an HIV physician knowledgeable about cognition, a neurologist, a psychiatrist, and a pharmacist specialized in HIV. Participants will also be asked to have a lumbar puncture in order to measure HIV viral load in the Cerebrospinal Fluid. Treatment recommendations will be made and participants will be followed for six months. The study will recruit up to 50 people living with HIV to enter the initial phase of investigation. Twenty-five of those participants will be selected for the study based on an extensive investigation and willingness to have a lumbar puncture for the measurement of HIV in the Cerebrospinal Fluid.

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